The Science Behind Fasting, Fat, and Metabolism


Many thinks that fasting help in weight loss. Is it true? Keep reading this blog topic by CRB Tech Reviews to know more about fasting, fats and metabolic.

Metabolites are some substances produced by a biological process, like the glucose generated in the metabolism of complex sugars and starches, or amino acids used in the biosynthesis of proteins.

How does mammals keep two biologically crucial metabolites in proper balance during times when they are feeding, sleeping, and fasting? New research studies provide some insight that might also be helpful in dealing with obesity.


Findings from UT Southwestern Medical Center point to an interesting corelation between body fat and your liver. Fat cells help the liver to regulate both glucose and uridine, a metabolite that plays a role in a wide range of processes, including storing glucose reserves, building RNA molecules, and producing proteins. Glucose is used for energy, but uridine is crucial for cellular function, growth, and repair. It’s essentially a building block for your body.

The liver is the main producer of uridine, but it turns out only when you are in a filled state. In dietary studies, the researchers found that prolonged exposure to a high-fat diet blunted the effects of fasting on reducing body temperature, an effect that is also associated with obesity. This study shows when you are in a state of fasting; your body’s fat cells take up uridine production. This cause increased activity in the fat cells, which leads to a faster burning metabolic state.


A regulatory model for energy homeostasis as in fasting/refeeding. The liver is the predominant biosynthetic organ and contributor to plasma uridine in the fed state, whereas the adiposity dominates uridine biosynthetic activity in the fasted state. Bile excretion is the primary mechanism for plasma uridine clearance. As nutrient intake triggers bile release, plasma uridine levels are raised during fasting and drop rapidly in the postprandial state. The fasting-associated with increase of plasma uridine elicits a hypothalamic response culminating in body temperature lowering, whereas bile-mediated uridine release promotes a decline of plasma uridine and enhances insulin sensitivity.

The real purpose of this study was to give a clear understanding of the role fat cells play in the production of uridine. Knowing that fat takes over uridine production during fasting indicates that the body is always working towards more glucose metabolism and cellular functions. The findings of this research could impact a lot, the way we deal with diseases like diabetes and obesity.

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